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KMID : 0545119980080030277
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Journal of Microbiology and Biotechnology
1998 Volume.8 No. 3 p.277 ~ p.279
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Hepatoprotective Effect of Extracellular Polymer Produced by Submerged Culture of Ganoderma lucidum WK-003
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Song, Chi Hyun
Yang, Byung Keun/Ra, Kyung Soo/Shon, Dong Hwan/Park, Eun Jeon/Go, Geon Il/Kim, Young Hwoan
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Abstract
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An extracellular polymer (exo-polymer) with hepatoprotective properties was produced after a 6-day submerged mycelial culture of Ganoderma lucidum WK-003. The glutamic pyruvic transaminase (GPT) activities in the serum of intoxicated Sprague-Dawley rats were decreased from 871 to 263 by the oral administration of the exopolymer (20 ㎎/㎏/day) for 4 consecutive days. Rhamnose, arabinose, xylose, mannose, galactose, and glucose were found in the exo-polymer along with aspartic acid, glutamic acid, histidine, serine, glycine, arginine, alanine, tryptophan, valine, phenylalanine, isoleucine, and leucine.
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